Mechanical loading disrupts osteocyte plasma membranes which initiates mechanosensation events in bone
نویسندگان
چکیده
منابع مشابه
Osteocyte Shape and Mechanical Loading
There is considerable variation in the shape of osteocyte lacunae, which is likely to influence the function of osteocytes as the professional mechanosensors of bone. In this review, we first discussed how mechanical loading could affect the shape of osteocyte lacunae. Recent studies show that osteocyte lacunae are aligned to collagen. Since collagen fiber orientation is affected by loading mod...
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Bone is removed or replaced in defined locations by targeting osteoclasts and osteoblasts in response to its local history of mechanical loading. There is increasing evidence that osteocytes modulate this targeting by their apoptosis, which is associated with locally increased bone resorption. To investigate the role of osteocytes in the control of loading-related modeling or remodeling, we stu...
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Bone responds with increased bone formation to mechanical loading, and the time course of bone formation after initiating mechanical loading is well characterized. However, the regulatory activities governing the loading-dependent changes in gene expression are not well understood. The goal of this study was to identify the time-dependent regulatory mechanisms that governed mechanical loading-i...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2017
ISSN: 0736-0266,1554-527X
DOI: 10.1002/jor.23665